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Alpha&ESM hFolds

A database for the comparison of structural models predicted by ESMFold and AlphaFold2 for 42,942 human proteins.
Part of the Bioinformatics Sweeties collection.

Protein information Download JSON
Protein name NACHT, LRR and PYD domains-containing protein 3
Gene name NLRP3
UniProt accession Q96P20
Sequence length 1036
Protein source SwissProt (reviewed)
Signal/Transit peptide Absent
Highest-coverage PDB Chain 7pzc_A
PDB Chain coverage 0.97
Experimental method (Resolution) Electron Microscopy (3.9 Å)

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
AlphaFold2
Alignment statistics
Structure alignment scores
TM-score 0.58
RMSD 4.25 Å
GDT 0.42
TM-score pLDDT≥50 0.61
TM-score pLDDT≥70 0.62
TM-score pLDDT≥90 0.71
Sequence coverage
ESMFold start - end 161 - 1036
AlphaFold2 start - end 170 - 1036
Alignment length 1080
Match positions 567
Mismatch positions 96
Gap positions (Gap opens) 373 (18)
Model quality statistics
  ESMFold AlphaFold2 Consensus
# of residues with pLDDT ≥ 50 (%) 978 (94.4%) 922 (89.0%) 910 (87.84%)
# of residues with pLDDT ≥ 70 (%) 868 (83.78%) 832 (80.31%) 819 (79.05%)
# of residues with pLDDT ≥ 90 (%) 513 (49.52%) 480 (46.33%) 428 (41.31%)

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)