Alpha&ESM hFolds

A database for the comparison of structural models predicted by ESMFold and AlphaFold2 for human proteins.
Now updated with Quality Assessment and Functional characterization of the models.
Part of the Bioinformatics Sweeties collection.

Protein information Download JSON
Protein name Galactose-1-phosphate uridylyltransferase
Gene name GALT
UniProt accession P07902
Sequence length 379
Protein source SwissProt (reviewed)
Signal/Transit peptide Absent
Highest-coverage PDB Chain 6gqd_A
PDB Chain coverage 0.9
Experimental method (Resolution) X-ray diffraction (1.52 Å)

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
AlphaFold2
Structure alignment scores
TM-score 0.9
RMSD 1.99 Å
GDT 0.84
Sequence coverage
ESMFold start - end 20 - 379
AlphaFold2 start - end 21 - 379
Alignment length 362
Match positions 347
Mismatch positions 10
Gap positions (Gap opens) 22 (4)
Self-assessment ESMFold AlphaFold2
Mean pLDDT 85.32 91.68
External validation ESMFold AlphaFold2
DeepAccNet mean pLDDT 82.22 98.68
QMEANDisCo mean pLDDT 76.6 84.6
QATEN mean pLDDT 69.29 70.52

AlphaFold is better than ESMFold according to 3/3 external QA tools

 Name Type Start End TM-score ESMFold
pLDDT 		AlphaFold2
pLDDT
GalP_UDP_transf Domain 23 196 0.95 85.0 93.25
GalP_UDP_tr_C Domain 203 368 0.94 86.69 97.34

No Pathogenic variations could be retrieved from UniProt

 Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
PDB (6gqd_A)
Structure alignment scores
TM-score 0.94
RMSD 2.15 Å
Sequence coverage
ESMFold start - end 24 - 370
PDB start - end 1 - 339
Alignment length 349
Match positions 316
Mismatch positions 21
ESMFold gap positions 2
PDB gap positions 42
Gap opens 9

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
AlphaFold2
PDB (6gqd_A)
Structure alignment scores
TM-score 0.98
RMSD 1.22 Å
Sequence coverage
AlphaFold2 start - end 25 - 370
PDB start - end 1 - 339
Alignment length 346
Match positions 328
Mismatch positions 11
AlphaFold2 gap positions 0
PDB gap positions 40
Gap opens 5