Alpha&ESM hFolds

A database for the comparison of structural models predicted by ESMFold and AlphaFold2 for human proteins.
Now updated with Quality Assessment and Functional characterization of the models.
Part of the Bioinformatics Sweeties collection.

Protein information Download JSON
Protein name Factor associated with metabolism and energy
Gene name CCDC198
UniProt accession Q9NVL8
Sequence length 296
Protein source SwissProt (reviewed)
Signal/Transit peptide Absent

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
AlphaFold2
Structure alignment scores
TM-score 0.2
RMSD 5.76 Å
GDT 0.15
TM-score pLDDT≥50 0.45
TM-score pLDDT≥70 0.0
TM-score pLDDT≥90 0.0
Sequence coverage
ESMFold start - end 85 - 251
AlphaFold2 start - end 8 - 253
Alignment length 320
Match positions 0
Mismatch positions 93
Gap positions (Gap opens) 203 (15)
Self-assessment ESMFold AlphaFold2
Mean pLDDT 45.15 59.4
External validation ESMFold AlphaFold2
DeepAccNet mean pLDDT 24.57 23.26
QMEANDisCo mean pLDDT 52.6 43.1
QATEN mean pLDDT 31.41 27.58

ESMFold is better than AlphaFold according to 3/3 external QA tools

 Name Type Start End TM-score ESMFold
pLDDT 		AlphaFold2
pLDDT
DUF4619 Family 1 296 0.22 45.15 59.4

No Pathogenic variations could be retrieved from UniProt