Alpha&ESM hFolds

A database for the comparison of structural models predicted by ESMFold and AlphaFold2 for human proteins.
Now updated with Quality Assessment and Functional characterization of the models.
Part of the Bioinformatics Sweeties collection.

Protein information Download JSON
Protein name Putative uncharacterized protein C6orf50
Gene name C6orf50
UniProt accession Q9HD87
Sequence length 102
Protein source SwissProt (reviewed)
Signal/Transit peptide Absent

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
AlphaFold2
Structure alignment scores
TM-score 0.72
RMSD 2.27 Å
GDT 0.7
TM-score pLDDT≥50 0.66
TM-score pLDDT≥70 0.0
TM-score pLDDT≥90 0.0
Sequence coverage
ESMFold start - end 8 - 102
AlphaFold2 start - end 6 - 102
Alignment length 97
Match positions 91
Mismatch positions 4
Gap positions (Gap opens) 7 (2)
Self-assessment ESMFold AlphaFold2
Mean pLDDT 49.2 53.55
External validation ESMFold AlphaFold2
DeepAccNet mean pLDDT 51.76 54.96
QMEANDisCo mean pLDDT 43.3 50.2
QATEN mean pLDDT 45.44 40.89

AlphaFold is better than ESMFold according to 2/3 external QA tools

No Pfam entries annotated on this protein

No Pathogenic variations could be retrieved from UniProt