Alpha&ESM hFolds

A database for the comparison of structural models predicted by ESMFold and AlphaFold2 for 42,942 human proteins.
Part of the Bioinformatics Sweeties collection.

Protein information Download JSON
Protein name NACHT, LRR and PYD domains-containing protein 3
Gene name NLRP3
UniProt accession Q96P20
Sequence length 1036
Protein source SwissProt (reviewed)
Signal/Transit peptide Absent
Highest-coverage PDB Chain 7pzc_A
PDB Chain coverage 0.97
Experimental method (Resolution) Electron Microscopy (3.9 Å)

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
AlphaFold2
Alignment statistics
Structure alignment scores
TM-score 0.58
RMSD 4.25 Å
GDT 0.42
TM-score pLDDT≥50 0.61
TM-score pLDDT≥70 0.62
TM-score pLDDT≥90 0.71
Sequence coverage
ESMFold start - end 161 - 1036
AlphaFold2 start - end 170 - 1036
Alignment length 1080
Match positions 567
Mismatch positions 96
Gap positions (Gap opens) 373 (18)
Model quality statistics
  ESMFold AlphaFold2 Consensus
# of residues with pLDDT ≥ 50 (%) 978 (94.4%) 922 (89.0%) 910 (87.84%)
# of residues with pLDDT ≥ 70 (%) 868 (83.78%) 832 (80.31%) 819 (79.05%)
# of residues with pLDDT ≥ 90 (%) 513 (49.52%) 480 (46.33%) 428 (41.31%)

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
ESMFold
PDB (7pzc_A)
Alignment statistics
Structure alignment scores
TM-score 0.73
RMSD 4.74 Å
TM-score pLDDT≥50 0.75
TM-score pLDDT≥70 0.77
TM-score pLDDT≥90 0.76
Sequence coverage
ESMFold start - end 94 - 1034
PDB start - end 99 - 1008
Alignment length 976
Match positions 782
Mismatch positions 93
ESMFold gap positions 135
PDB gap positions 161
Gap opens 21

Sequence alignment (from structure superimposition) Download FASTA

Model Confidence: Very high (pLDDT ≥ 90) High (90 > pLDDT ≥ 70) Low (70 > pLDDT ≥ 50) Very low (pLDDT < 50)

Structure superimposition
AlphaFold2
PDB (7pzc_A)
Alignment statistics
Structure alignment scores
TM-score 0.57
RMSD 4.51 Å
TM-score pLDDT≥50 0.6
TM-score pLDDT≥70 0.61
TM-score pLDDT≥90 0.69
Sequence coverage
AlphaFold2 start - end 168 - 1036
PDB start - end 151 - 1010
Alignment length 1077
Match positions 559
Mismatch positions 93
AlphaFold2 gap positions 358
PDB gap positions 384
Gap opens 20